Authors:
Harris, D., Muzzopappa, F., Glaser, F., Wilson, A., Kirilovsky, D., & Adir, N.
Received 2 October 2019, Revised 19 March 2020, Accepted 27 April 2020, Available online 30 April 2020, Version of Record 15 May 2020.
Highlights
• The C-terminal domain homolog (CTDH) of cyanobacterial OCP uptakes carotenoids from membranes.
• The crystal structure of the Anabaena CTDH protein reveals C-terminal tail dynamics.
• Molecular dynamics simulations reveal critical residues necessary for this dynamic behavior.
• Mutagenesis of these residues shows impairment of carotenoid uptake and delivery by the CTDH.
• The mechanism of uptake and transfer of hydrophobic carotenoids by soluble proteins is proposed.
